Valerio Mieli was born on January 27, 1978 in Rome, Lazio, Italy.

After a master of philosophy at the University of Rome («La Sapienza»), he studied at the Columbia University and the University of Eastern Piedmont «Amedeo Avogadro». He obtained a diploma of direction at the Centro sperimentale di cinematografia. He is a member of the Accademia del cinema italiano.

In 2009, he published a novel, "Ten Winters", (Rizzoli editions).

He directed the movies "Dieci inverni (Ten Winters)" (2009) and "Ricordi?" (2018).