Edna MacAfee (sometimes credited as Edna Macafee) was a minor character actress and local stage performer best known for her brief film appearances in the early 1970s. She played the role of Agnes Abercrombi, the enigmatic elderly resident (and implied witch) in the 1973 horror film Warlock Moon, directed by William Herbert. In that production, she was cast as a "dignified and aged stage actress" to bring authenticity to the part, and production anecdotes describe her as lively and memorable off-set—such as mistaking a urinal for a purse holder in a restroom, which amused the crew without correction. Her only other credited film role was a small part as "Seller at Swapmeet" in the 1974 action film Dirty Mary, Crazy Larry.

Beyond these, MacAfee had a more active career in regional theater around the San Francisco Bay Area, particularly in Palo Alto, California. For instance, in May 1973—around the same time Warlock Moon was in production—she appeared as Alma's mother in a local staging of Tennessee Williams's Summer and Smoke at the Manhattan Playhouse, alongside actors like Sally Cotton and Ed Cerney. Blogs and reviews of Warlock Moon often praise her performance as a highlight, noting her natural cackling and ease in the witch-like role, which aligned with her background in stage work rather than professional screen acting.