Melissa Mason made her screen debut in The Yacht Party (1932) as dancer and singer. While she went uncredited on the short's soundtrack, the role led to various Broadway performances including White Horse Inn (1936), Night of Love (1941) and George White's Music Hall Varieties (1933) which was her Broadway debut. She never became a prominent performer, and after the 1940s she disappeared from film and radio, making her last on-screen performance in Radio City Revels (1938).

Melissa Mason specialized in extreme high kicking and she was known for her ability to swing her leg in 360 degrees vertically like it was her shoulder.