Maxon Crumb is the younger brother of underground cartoonist Robert Crumb and Charles Crumb, and the uncle of Sophie Crumb.

His early work can be found in publications such as Weirdo, Liquidator, Maxon's Poe (1997), and Crumb Family Comics (Last Gasp, 1998).

His first published novel, HardCore Mother (2000) was a study of incest and sadism. After its publication in 2001, his work found a wider audience.