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James Danforth Quayle (born February 4, 1947) is an American politician and lawyer who served as the 44th vice president of the United States from 1989 to 1993. Quayle was also a U.S. representative from 1977 to 1981 and a U.S. senator from 1981 to 1989 from the state of Indiana.

A native of Indianapolis, Indiana, Quayle spent most of his childhood in Paradise Valley, a suburb of Phoenix, Arizona. He married Marilyn Tucker in 1972 and obtained his J.D. degree from the Indiana University Robert H. McKinney School of Law in 1974. Quayle practiced law in Huntington, Indiana with his wife before his election to the United States House of Representatives in 1976. In 1980 Quayle was elected to the U.S. Senate.

In 1988, Vice President and Republican presidential nominee George H. W. Bush chose Quayle as his running mate. Quayle's vice presidential debate against Democratic candidate Lloyd Bentsen was notable for the "Senator, you're no Jack Kennedy" incident. The Bush/Quayle ticket won the 1988 election over the Democratic ticket of Michael Dukakis and Bentsen, and Quayle became vice president in January 1989. As vice president, he made official visits to 47 countries and was appointed chairman of the National Space Council. He secured re-nomination for vice president in 1992, but Democrat Bill Clinton and his running mate, Al Gore, defeated the Bush/Quayle ticket.

In 1994 Quayle published his memoir, Standing Firm. He declined to run for President in 1996 because he was suffering from phlebitis. Quayle sought the Republican presidential nomination in 2000 but later withdrew from the campaign and supported the eventual winner, George W. Bush. He joined Cerberus Capital Management, a private equity firm, in 1999.