Born in Zaragoza in 1980, she has worked as camera operator, assistant, electrician, cinematographer, script editor, editor, scriptwriter and director. She studied at the University of Zaragoza and at the ECAM, where she earned a degree as cinematography director in 2006.

After her debut as director in Sonrisas (2005, short film), she directed other short films such as Niño Balcón and Chan Chán.

Palomero's directorial debut in a feature film, the 2020 coming-of-age drama Schoolgirls, earned her two Feroz Awards (Best Direction & Best Screenplay) and two Goya Awards (Best New Director & Best Original Screenplay).