Youssef Girgis Salib was born in Alexandria. He graduated in 1960 from the electronic engineering division of the Faculty of Engineering. Thereafter he worked as an engineer before devoting himself to acting in 1985.

He made his acting debut in the theatrical production Midaq Alley. Among the television productions that he participated in are "Al Souq" , “(Kasabna) Al Qadiyah” and “Al Dish wa Al Mish”. Youssef’s roles have varied from comic ones to portrayals of a police officer and a family head.