Anna Panagiotopoulou (Greek: Άννα Παναγιωτοπούλου; 30 July 1945 – 4 May 2024) was a famous Greek actress that has starred in many series, films and theatrical plays.

She became famous after starring in the Greek series Madam Sousou in 1986.

A major hit of her career was starring as one of the three Haritou sisters, Olga, in the Greek hit series Oi Treis Harites during 1990-92. In 1993 she wrote and starred in the series Rosalia (with Eleni Gerasimidou). The series lasted only 1 season due to low ratings. In 1995, she starred in another successful series Ntoltse Vita as Christina Markatou. The series draw high ratings and lasted 2 seasons.

Panayiotopoulou also enjoyed a successful film career, having appeared in several commercially and critically successful films such as Safe Sex (1999) and To Klama Vgike Apo ton Paradiso (Crying... Silicon Tears) (2001).